FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AxnL67P.KI
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General Information
Symbol
Dmel\AxnL67P.KI
Species
D. melanogaster
Name
FlyBase ID
FBal0351596
Feature type
allele
Associated gene
Dmel\Axn
Associated Insertion(s)
TI{TI}AxnL67P.KI
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Anvarian et al., 2016)
Progenitor genotype
AxnKO
(Anvarian et al., 2016)
Associated Insertion(s)
TI{TI}AxnL67P.KI
Cytology
Description

Knock-in of an Axn cDNA containing a L67P substitution (equivalent to L101P in human Axin, which is associated with cancer) into the attP site present in the AxnKO locus.

(Anvarian et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:30,031,215..30,031,215 [+]
Nucleotide change:

T30031215C

Amino acid change:

L67P | Axn-PA; L67P | Axn-PB; L67P | Axn-PC; L67P | Axn-PD; L67P | Axn-PE; L67P | Axn-PF; L67P | Axn-PG

Comment:

Analogous L101P mutation in human AXIN1 implicated in colorectal cancer; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Anvarian et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA
      (Anvarian et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      The disease model uses AxnL67P.KI clones in the posterior of the wing disc.

      (Anvarian et al., 2016)
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Anvarian et al., 2016)
      AXIN1:p.Leu101Pro
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      AxnL67P.KI wing disc clones seem larger than controls at 29[o]C, but not at 25[o]C or 18[o]C.

      (Anvarian et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AxnL67P.KI
      Axn[KI, L67P]
      (Anvarian et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)