FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AxnV72R.KI
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General Information
Symbol
Dmel\AxnV72R.KI
Species
D. melanogaster
Name
FlyBase ID
FBal0351597
Feature type
allele
Associated gene
Dmel\Axn
Associated Insertion(s)
TI{TI}AxnV72R.KI
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Anvarian et al., 2016)
Progenitor genotype
AxnKO
(Anvarian et al., 2016)
Associated Insertion(s)
TI{TI}AxnV72R.KI
Cytology
Description

Knock-in of an Axn cDNA containing a V72R substitution (equivalent to L106R in human Axin, which is associated with cancer) into the attP site present in the AxnKO locus.

(Anvarian et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3R:30,031,229..30,031,230 [+]
Nucleotide change:

GT30031229CG

Amino acid change:

V72R | Axn-PA; V72R | Axn-PB; V72R | Axn-PC; V72R | Axn-PD; V72R | Axn-PE; V72R | Axn-PF; V72R | Axn-PG

Reported amino acid change:

V72R

Comment:

Analogous L106R mutation in human AXIN1 implicated in hepatocellular carcinoma; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Anvarian et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA
      (Anvarian et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      The disease model uses AxnV72R.KI clones in the posterior of the wing disc.

      (Anvarian et al., 2016)
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Anvarian et al., 2016)
      AXIN1:p.Leu106Arg
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      UniProtKB/Swiss-Prot variant: VAR_015589
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At 29[o]C, AxnV72R.KI wing disc clones are significantly larger than control clones, giving rise to tumor-like growths, and exhibit smooth edges instead of the jagged and elongated shape in controls. At 18[O]C and 25[O]C, the clones appear normal in the pouch but have aberrantly smooth edges in the prospective notum and hinge.

      (Anvarian et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AxnV72R.KI
      Axn[KI, V72R]
      (Anvarian et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)