FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AxnV72R.Y86R.F87R.KI
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General Information
Symbol
Dmel\AxnV72R.Y86R.F87R.KI
Species
D. melanogaster
Name
FlyBase ID
FBal0351599
Feature type
allele
Associated gene
Dmel\Axn
Associated Insertion(s)
TI{TI}AxnV72R.Y86R.F87R.KI
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Anvarian et al., 2016)
Progenitor genotype
AxnKO
(Anvarian et al., 2016)
Associated Insertion(s)
TI{TI}AxnV72R.Y86R.F87R.KI
Cytology
Description

Knock-in of an Axn cDNA containing a V72R substitution (equivalent to L106R in human Axin, which is associated with cancer) together with "aggregon suppressor" mutations Y86R and F87R into the attP site present in the AxnKO locus.

(Anvarian et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Anvarian et al., 2016)
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      AxnV72R.Y86R.F87R.KI wing disc clones are significantly larger than control clones, giving rise to tumor-like growths.

      (Anvarian et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AxnV72R.Y86R.F87R.KI
      Axn[KI, V72R, Y86R, F87R]
      (Anvarian et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)