FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\ImpG00080.CRISPR-ΔPLD
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General Information
Symbol
Dmel\ImpG00080.CRISPR-ΔPLD
Species
D. melanogaster
Name
FlyBase ID
FBal0351610
Feature type
allele
Associated gene
Dmel\Imp
Associated Insertion(s)
P{PTT-un}G00080
TI{TI}CRISPR-ΔPLD
Carried in Construct
Also Known As
GFP-Imp, G080-GFP-Imp
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Vijayakumar et al., 2019)
gene targeting by homologous recombination
(Vijayakumar et al., 2019)
Progenitor genotype
P{PTT-un}G00080
(Vijayakumar et al., 2019)
Associated Insertion(s)
P{PTT-un}G00080
TI{TI}CRISPR-ΔPLD
Cytology
Description

Sequence containing stop codons and a loxP-flanked Disc\RFP3xP3.cUa marker has been introduced into the Imp coding sequence, such that the Imp proteins produced lack the prion-like domain (PLD). The progenitor P{PTT-un}G00080 insertion is still present on the chromosome.

(Vijayakumar et al., 2019)
Allele components
Component
Use(s)
Inserted element
P{PTT-un}
Tagged with
EGFP
Tag:polyHis
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ImpG00080.CRISPR-ΔPLD homozygous mutant adults have polarized growth defects in some mushroom body γ neurons, with no defects in overall projection patterns of the γ neuron population, compared to controls.

      (Vijayakumar et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      G080-GFP-Imp-ΔPLD
      (de Queiroz et al., 2025)
      GFP-Imp-CRISPR-ΔPLD
      (Vijayakumar et al., 2019)
      ImpG00080.CRISPR-ΔPLD
      Name Synonyms
      Secondary FlyBase IDs
        References (2)