FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sandΔ
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General Information
Symbol
Dmel\sandΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0351738
Feature type
allele
Associated gene
Dmel\sand
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Klassen et al., 2017)
Mutagen
FLPase
(Klassen et al., 2017)
Progenitor genotype
PBac{RB}sande00867
(Klassen et al., 2017)
PBac{RB}unoe00152
(Klassen et al., 2017)
Caused by aberration
Df(2R)sandΔ
Cytology
Description

FRT-mediated recombination between the progenitors (PBac{RB}sande00867 and PBac{RB}CG8712e00152) results in deletion of the entire sand coding sequence along with most of the CG8712 coding sequence.

(Klassen et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  heart conduction disease
      CEA
      (Klassen et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sandΔ homozygous adults exhibit age-dependent heart function defects, namely a decreased ability to transition from heart contraction to heart relaxation, with some animals rarely or never displaying heart relaxation; they display increased heartbeat period, increased systolic and diastolic intervals, decreased fractional shortening, decreased stroke volume, decreased number of contractions and decreased cardiac output. Individual sarcomeres exhibit a fibrillatory state during extended systoles, contracting and relaxing out of phase with one another.

      Aged sandΔ/Df(2R)BSC267 transheterozygous adults also exhibit increased heartbeat period, increased systolic and diastolic intervals, decreased number of contractions and decreased cardiac output.

      (Klassen et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sandΔ
      sandmanΔ
      (Klassen et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)