FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Zzzz\GGGGCC44.UAS.LDS.GFP
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General Information
Symbol
Zzzz\GGGGCC44.UAS.LDS.GFP
Species
a. artificial
Name
FlyBase ID
FBal0352678
Feature type
allele
Associated gene
Zzzz\GGGGCC
Associated Insertion(s)
Carried in Construct
P{UAS-LDS.(GGGGCC)44.GR-GFP}
Transgenic product class
short_tandem_repeat_expansion
(Goodman et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
short_tandem_repeat_expansion
(Goodman et al., 2019)
Mutagen
in vitro construct
(Goodman et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-LDS.(GGGGCC)44.GR-GFP}
Cytology
Description

UASt regulates expression of 44 GGGGCC repeats preceded by 114 base pairs of intronic (leader) sequence (LDS) found upstream of the G4C2 repeat in Hsap\C9orf72 in patients. This is followed by a GFP tag in the GR reading frame.

(Goodman et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Zzzz\GGGGCC
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Goodman et al., 2019)

      This construct encodes only the RNA repeat motif.

      C9orf72:n.intron1[44GGGGCC]
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      C9ORF72, (GGGGCC)n REPEAT EXPANSION
      C9ORF72, (G4C2)n REPEAT EXPANSION
      Associated human disease model(s)
      External database links
      ClinVar: C9orf72_31151
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Zzzz\GGGGCC44.UAS.LDS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (3)