FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HmutNLS3
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General Information
Symbol
Dmel\HmutNLS3
Species
D. melanogaster
Name
FlyBase ID
FBal0353220
Feature type
allele
Associated gene
Dmel\H
Associated Insertion(s)
TI{TI}HmutNLS3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Wolf et al., 2019)
Progenitor genotype
HattP
(Wolf et al., 2019)
Associated Insertion(s)
TI{TI}HmutNLS3
Cytology
Description

A cDNA fragment containing mutated H sequence has been reintroduced into the attP site present in HattP, resulting in a H locus carrying a mutation in NLS3 (nuclear localization signal 3).

(Wolf et al., 2019)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      HmutNLS3 leads to dominant loss of bristles in the head and thorax, a phenotype that is more severe in homozygotes than in heterozygotes. Homozygous wing discs show a nearly complete absence of sensory organ precursors.

      (Wolf et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      HmutNLS3 has macrochaeta phenotype, suppressible | partially by Su(H)[+]/Su(H)attP

      (Wolf et al., 2019)

      HmutNLS3 has microchaeta phenotype, suppressible | partially by Su(H)[+]/Su(H)attP

      (Wolf et al., 2019)
      Suppressor of
      Statement
      Reference

      HmutNLS3, Scer\GAL4bi-omb-Gal4 is a suppressor | partially of wing phenotype of Scer\GAL4bi-omb-Gal4, Su(H)UAS.cUa

      (Wolf et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      H*NLS3
      (Wolf et al., 2019)
      HmutNLS3
      Name Synonyms
      Secondary FlyBase IDs
        References (1)