FlyBase Allele Report: Dmel\H[attP]

General Information

Symbol

Dmel\H^attP

Species

D. melanogaster

Name

FlyBase ID

FBal0326570

Feature type

allele

Associated gene

Dmel\H

Associated Insertion(s)

TI{TI}H^attP

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

cre recombinase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Praxenthaler et al., 2015)

Mutagen

cre recombinase

(Praxenthaler et al., 2015)

Progenitor genotype

H^attP.w+

(Praxenthaler et al., 2015)

Associated Insertion(s)

TI{TI}H^attP

Cytology

Description

A 5.1kb fragment comprising the entire H coding region and some of the 5' and 3' UTR sequences has been deleted and replaced by sequence corresponding to a single attP site and a single loxP site. Generated by excision of the loxP cassette present in H^attP.w+.

(Praxenthaler et al., 2015)

Allele components

Component

Use(s)

Also carries

attP

integrase target site

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | larval stage

(Frankenreiter et al., 2021, Wolf et al., 2019)

decreased size | adult stage | dominant

(Mönch et al., 2024)

hyperplasia | third instar larval stage

(Praxenthaler et al., 2017)

increased cell number | pharate adult stage (with H^mutNLS3NES)

(Mönch et al., 2024)

lethal

(Mönch et al., 2024)

lethal - all die before end of P-stage

(Wolf et al., 2019)

partially lethal - majority live (with H^Cfs)

(Smylla et al., 2016)

some die during pharate adult stage

(Wolf et al., 2019)

some die during P-stage

(Mönch et al., 2024)

viable (with H^cwt)

(Smylla et al., 2016)

viable (with H^ΔM1-2)

(Smylla et al., 2016)

viable (with H^ΔM1)

(Smylla et al., 2016)

viable (with H^ΔM2)

(Smylla et al., 2016)

viable (with H^ΔM3)

(Smylla et al., 2016)

visible | adult stage

(Praxenthaler et al., 2017, Smylla et al., 2016)

visible | adult stage (with H^Cfs)

(Smylla et al., 2016)

visible | adult stage (with H^cwt)

(Smylla et al., 2016)

visible | adult stage (with H^ΔM1-2)

(Smylla et al., 2016)

visible | adult stage (with H^ΔM1)

(Smylla et al., 2016)

visible | adult stage (with H^ΔM2)

(Smylla et al., 2016)

visible | adult stage (with H^ΔM3)

(Smylla et al., 2016)

visible | adult stage | dominant

(Mönch et al., 2024)

visible | pharate adult stage (with H^mutNLS3NES)

(Mönch et al., 2024)

visible | pharate adult stage (with H^WA)

(Mönch et al., 2024)

Phenotype Manifest In

embryonic/larval crystal cell | decreased number | larval stage

(Frankenreiter et al., 2021)

external sensory organ precursor cell | larval stage

(Wolf et al., 2019)

macrochaeta

(Wolf et al., 2019, Smylla et al., 2016)

macrochaeta (with H^Cfs)

(Smylla et al., 2016)

macrochaeta (with H^cwt)

(Smylla et al., 2016)

macrochaeta (with H^ΔM1-2)

(Smylla et al., 2016)

macrochaeta (with H^ΔM1)

(Smylla et al., 2016)

macrochaeta (with H^ΔM2)

(Smylla et al., 2016)

macrochaeta (with H^ΔM3)

(Smylla et al., 2016)

macrochaeta | adult stage

(Praxenthaler et al., 2017)

mechanosensory chaeta | absent | pharate adult stage (with H^mutNLS3NES)

(Mönch et al., 2024)

mechanosensory chaeta | absent | pharate adult stage (with H^WA)

(Mönch et al., 2024)

mechanosensory chaeta | adult stage | decreased number

(Mönch et al., 2024)

microchaeta

(Wolf et al., 2019)

tormogen cell | increased number | pharate adult stage (with H^mutNLS3NES)

(Mönch et al., 2024)

wing disc

(Wolf et al., 2019)

wing disc | third instar larval stage

(Praxenthaler et al., 2017)

wing vein L5

(Mönch et al., 2024, Smylla et al., 2016)

Detailed Description

Statement

Reference

H^mutNLS3 heterozygous adults exhibit mild but significant loss of bristles in the head and thorax. Homozygous wing discs show a nearly complete absence of sensory organ precursors.

(Wolf et al., 2019)

H^attP/+ flies lack several macrochaetae or display shaft to socket transformations, homozygous mutant larvae developed enlarged wing imaginal discs that contain no or sporadic sensory organ precursors.

(Praxenthaler et al., 2017)

Adult H^Cfs heterozygous mutants display bristle defects with, on average, 12 (out of 40 present in wild-type) of the large head and thorax bristles affected as well as shortened wing vein L5.

(Smylla et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

H^attP has visible | dominant | adult stage phenotype, suppressible by Su(H)[+]/Su(H)^attP

(Mönch et al., 2024)

Suppressor of

Statement

Reference

H^attP/H[+] is a suppressor of visible | adult stage phenotype of Delta^B2

(Smylla et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

H^attP has mechanosensory chaeta | adult stage phenotype, suppressible by Su(H)[+]/Su(H)^attP

(Mönch et al., 2024)

H^attP has macrochaeta phenotype, suppressible | partially by Su(H)[+]/Su(H)^attP

(Wolf et al., 2019)

H^attP has microchaeta phenotype, suppressible | partially by Su(H)[+]/Su(H)^attP

(Wolf et al., 2019)

Suppressor of

Statement

Reference

H^attP/H[+] is a suppressor of wing vein phenotype of Delta^B2

(Smylla et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

H^cwt, Su(H)^attP double-heterozygotes, H^mutNLS1, Su(H)^attP double-heterozygotes, H^mutNLS2, Su(H)^attP double-heterozygotes, H^mutNLS1NLS2, Su(H)^attP double-heterozygotes or H^mutNES, Su(H)^attP double-heterozygotes do not show loss of sensory bristles in the head and thorax.

(Wolf et al., 2019)

The wing notching phenotype of Df(1)N-54l9/+ heterozygotes is largely suppressed if they are also heterozygous for H^attP.

The vein thickening and vein deltas characteristic for H^attP/+ adults is partially suppressible by combination with a single copy of H^attP.

(Smylla et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

94608

w^*; TI{TI}H^attP/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

H^attP

(Mönch et al., 2024, Maier et al., 2023, Frankenreiter et al., 2021, Gahr et al., 2019, Wolf et al., 2019, Praxenthaler et al., 2017, Smylla et al., 2016, Praxenthaler et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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