FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DhprG16D.UAS.Tag:HA
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General Information
Symbol
Dmel\DhprG16D.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0353334
Feature type
allele
Associated gene
Dmel\Dhpr
Associated Insertion(s)
Carried in Construct
P{UAS-Dhpr.G16D.HA}
Key Links
Transgenic product class
missense_variant
(Zhou et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Zhou et al., 2019)
Mutagen
in vitro construct
(Zhou et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-Dhpr.G16D.HA}
Cytology
Description

UAS regulatory sequences drive expression of Dhpr cDNA with a G16D mutation to render the enzyme inactive; tagged with 3xTag:HA.

(Zhou et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dhpr
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing DhprG16D.UAS.Tag:HA under the control of Scer\GAL4Mef2.PR results in a small but significant decrease in adult climbing ability, but does not have an obvious effect in the thorax muscles; muscle mitochondria also do not show obvious defects.

      DhprG16D.UAS.Tag:HA enhances the adult thorax muscle mitochondrial defects induced by Scer\GAL4Mef2.PR>DhprHMC05508, instead of rescuing them.

      Expressing DhprG16D.UAS.Tag:HA under the control of Scer\GAL4Cg.PA does not seem to lead to mitochondrial defects in the third instar larval fat body (as assessed by MitoGFP).under the control of Scer\GAL4Cg.PA does not seem to lead to mitochondrial defects in the third instar larval fat body (as assessed by MitoGFP).

      DhprG16D.UAS.Tag:HA enhances the larval fat body mitochondrial defects induced by Scer\GAL4Cg.PA>DhprHMC05508, instead of rescuing them.

      (Zhou et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      DhprG16D.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)