FB2026_03 , released September 17, 2026
Allele: Dmel\GluClαS278T
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General Information
Symbol
Dmel\GluClαS278T
Species
D. melanogaster
Name
FlyBase ID
FBal0356186
Feature type
allele
Associated gene
Dmel\GluClα
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Molina-Obando et al., 2019)
gene targeting by homologous recombination
(Molina-Obando et al., 2019)
Progenitor genotype
Cytology
Description

Amino acid replacement: S278T.

(Molina-Obando et al., 2019)

The S278T mutation is introduced into endogenous GluClα, rendering it picrotoxin-insensitive.

(Molina-Obando et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:19,763,744..19,763,744 [+]
Nucleotide change:

T19763744A

Amino acid change:

S200T | GluClalpha-PE; S278T | GluClalpha-PF; S278T | GluClalpha-PH; S278T | GluClalpha-PI; S279T | GluClalpha-PJ; S278T | GluClalpha-PK; S279T | GluClalpha-PL; S278T | GluClalpha-PM; S278T | GluClalpha-PN; S278T | GluClalpha-PO; S278T | GluClalpha-PP

Reported amino acid change:

S278T

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Molina-Obando et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
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      Disease
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      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
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      Genetic Interactions
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      Xenogenetic Interactions
      Statement
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      Complementation and Rescue Data
      Comments
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      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      GluClαS278T
      (Molina-Obando et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)