FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\c(3)GccΔ3
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General Information
Symbol
Dmel\c(3)GccΔ3
Species
D. melanogaster
Name
FlyBase ID
FBal0357226
Feature type
allele
Associated gene
Dmel\c(3)G
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Billmyre et al., 2019)
gene targeting by homologous recombination
(Billmyre et al., 2019)
Progenitor genotype
Cytology
Description

In-frame deletion that removes sequence encoding amino acids 465-471 (this deletion is within the predicted coiled-coil domain, but was picked as a site where the COILS score dipped, suggesting a loss of coiled-coil structure).

(Billmyre et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In c(3)GccΔ3 females, pachytene oocytes never fully assemble full-length synaptonemal complex (Corolla immunostaining).

      In c(3)GccΔ3 homozygous females, oocytes show a progressive decrease in X and 3rd homologous chromosome pairing during pachytene despite of no changes in DNA double strand break formation during early pachytene, disrupted centromere clustering despite of relatively normal centromere pairing, as compared to heterozygous and wild-type controls. These are associated with abnormal chromosomal recombination, compared to heterozygous and wild-type controls: severe reduction in X chromosome recombination, and abnormal 3rd chromosome recombination (decreased distal euchromatin recombination and severely increased proximal euchromatin recombination). In addition, there is a small frequency of X and 4th chromosome non-disjunction events, which are virtually not observed in heterozygous and wild-type controls.

      (Billmyre et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      c(3)GccΔ3 has abnormal meiotic cell cycle | recessive | female phenotype, enhanceable by vilya826

      (Billmyre et al., 2019)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      c(3)GccΔ3
      (Billmyre et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)