FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4DBD.VT036267.PX
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General Information
Symbol
Scer\GAL4DBD.VT036267.PX
Species
S. cerevisiae
Name
FlyBase ID
FBal0358636
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{VT036267-GAL4.DBD.X}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Xie et al., 2019)
Progenitor genotype
Carried in construct
P{VT036267-GAL4.DBD.X}
Cytology
Description

VT036267 enhancer fragment is fused upstream of the GAL4(DBD)::Zip- hemidriver (component of the 'Split GAL4' system, contains the GAL4 DNA-binding domain).

(Xie et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
VT036267
Encoded product / tool
GAL4(DBD)::Zip-
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult protocerebral bridge 1 glomerulus-fan-shaped body-round body type a neuron | subset

      Comment: when combined with P{R37G12-p65.AD} (combination referred to as 'P-Fr-GAL4')

      (Xie et al., 2019)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inactivation of P-Fr neutrons by the expression of Ctet\tetXTNT-LC.UAS under the control of P-Fr split-Gal4 (Hsap\RELAAD.R37G12 with Scer\GAL4DBD.VT036267.PX) leads to resistance to sleep deprivation while it does not lead to any changes in the sleep/wake cycles, total duration of night time sleep, locomotion or mechanosensory responsiveness of flies when compared to control adults.

      Thermogenetic activation of P-Fr neurons via expression of TrpA1UAS.(B).cKa under the control of P-Fr split-Gal4 (Hsap\RELAAD.R37G12 with Scer\GAL4DBD.VT036267.PX) leads to significantly less sleep at night time, and a significant increase in locomotion of flies during nighttime with no change during daytime when compared to control adults.

      (Xie et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4DBD.VT036267.PX
      Name Synonyms
      Secondary FlyBase IDs
        References (1)