FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SLC6A3UAS.cHa
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General Information
Symbol
Hsap\SLC6A3UAS.cHa
Species
H. sapiens
Name
FlyBase ID
FBal0358972
Feature type
allele
Associated gene
Hsap\SLC6A3
Associated Insertion(s)
Carried in Construct
M{UAS-hSLC6A3.H}
Key Links
Transgenic product class
wild_type
(Hamilton et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hamilton et al., 2013)
Mutagen
in vitro construct
(Campbell et al., 2019, Hamilton et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-hSLC6A3.H}
Cytology
Description

UAS regulatory sequences drive expression of wild-type Hsap\SLC6A3.

(Campbell et al., 2019)

UAS regulatory sequences drive expression of Hsap\SLC6A3 coding sequences.

(Hamilton et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\SLC6A3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autism spectrum disorder
      modeled by DATfmn
      (Cartier et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The hyperactivity characteristic for DATfmn adult mutants is suppressed by expression of Hsap\SLC6A3Scer\UAS.cHa under the control of Scer\GAL4ple.PF. The circadian rhythm of the locomotor activity of DATfmn flies is not perturbed by the transgene expression.

      (Hamilton et al., 2014)

      Selective expression of Hsap\SLC6A3Scer\UAS.cHa in DA neurons (under the control of Scer\GAL4ple.PF) significantly reduces the hyperactivity found in DATfmn flies.

      (Hamilton et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Hsap\SLC6A3Scer\UAS.cHa
      Hsap\SLC6A3UAS.cCa
      Hsap\SLC6A3UAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hamilton
      (Hamilton et al., 2013)
      UAS construct a of Campbell
      Secondary FlyBase IDs
      • FBal0294000
      • FBal0347166
      References (6)