FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\matSK1
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General Information
Symbol
Dmel\matSK1
Species
D. melanogaster
Name
FlyBase ID
FBal0359826
Feature type
allele
Associated gene
Dmel\mat
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Li et al., 2020)
Progenitor genotype
Cytology
Description

11bp deletion, resulting in a frameshift mutation in the 5' part of the mat coding sequence. This produces a premature stop codon that results in a 78 residue peptide lacking the MA domain.

(Li et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      matSK1 adults exhibit lower lipid uptake in the Malpighian tubules upon clean injury due to lipid probe (FA C12) injection.

      matSK1 adults exhibit lower secretion rate of Malpighian tubules in both unchallenged and post-injury conditions.

      matSK1 adults die faster upon clean injury, systemic or oral infection with Ecc15.

      matSK1 adults exhibit an increased susceptibility to heat stress and oxidative stress.

      (Li et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      matSK1 has abnormal immune response phenotype, suppressible by Scer\GAL4Uro.PU/DuoxRNAi.UAS

      (Li et al., 2020)

      matSK1 has increased mortality | conditional phenotype, suppressible by Scer\GAL4Uro.PU/DuoxRNAi.UAS

      (Li et al., 2020)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      matSK1
      (Li et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)