FB2026_02 , released June 18, 2026
Allele: Dmel\upCD70-RFP
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General Information
Symbol
Dmel\upCD70-RFP
Species
D. melanogaster
Name
FlyBase ID
FBal0360095
Feature type
allele
Associated gene
Dmel\up
Associated Insertion(s)
TI{TI}upCD70-RFP
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Cao et al., 2020)
gene targeting by homologous recombination
(Cao et al., 2020)
Progenitor genotype
Associated Insertion(s)
TI{TI}upCD70-RFP
Cytology
Description

A stop codon has been introduced into exon 11 of the endogenous up locus; this is expected to result in a truncated protein that lacks the last 70 amino acids including the C-terminal Glu-rich segment. A loxP cassette containing a Disc\RFP3xP3.cUa marker has also been inserted, downstream of the stop codon.

(Cao et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
X:13,593,947..13,594,003 [-]
Comment:

A stop codon has been introduced into exon 11 of the endogenous up locus; this is expected to result in a truncated protein that lacks the last 70 amino acids including the C-terminal Glu-rich segment. A loxP cassette containing a Disc\RFP3xP3.cUa marker has also been inserted, downstream of the stop codon replacing 57 bases of endogenous up sequence.

(Jin, 2020.6.29)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TpnTCD70-RFP
      (Cao et al., 2020)
      upCD70-RFP
      (Jin, 2020.6.29)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)