FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Vps291
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General Information
Symbol
Dmel\Vps291
Species
D. melanogaster
Name
FlyBase ID
FBal0360202
Feature type
allele
Associated gene
Dmel\Vps29
Associated Insertion(s)
TI{ywing2+}Vps291
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ye et al., 2020)

amorphic allele - molecular evidence

(Ye et al., 2020)
Mutagen
CRISPR/Cas9
(Ye et al., 2020)
gene targeting by homologous recombination
(Ye et al., 2020)
Progenitor genotype
Associated Insertion(s)
TI{ywing2+}Vps291
Cytology
Description

The coding sequence of the endogenous Vps29 locus has been replaced by the dominantly marked TI{ywing2+} cassette (deleted sequence is 2L:1150852..1151420 , release 6 genome coordinates).

(Ye et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
complex_substitution
2L:1,150,852..1,151,420 [+]
Comment:

A region that extends from 11 bases upstream of the Vps29 coding sequence to 9bp downstream of the CDS has been deleted and replaced with the TI{ywing2+} cassette.

(Ye et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Electroretinogram readings in Vps291 homozygotes show poorly sustained transient potentials; in full-eye Vps291 clones, there is disrupted light-induced depolarization, with progressively decreased amplitudes and on/off transients. Vps291/Df(2L)Exel6004 individuals also show decreased ON-transients.

      Vps291 homozygous and Vps291/Df(2L)Exel6004 adults show age-dependent decrease in climbing activity. and age-dependent/light-dependent retinal vacuolization. Vps291/Df(2L)Exel6004 adults also show an increase in eye photoreceptors with increased numbers of lysosomes, multi-vesicle bodies and autophagic vacuoles, and cortical brain neurons with increased multi-lamellar bodies.

      The Vps291 larval NMJ presents increased number of boutons and decreased EJP amplitude upon high-frequency stimulation.

      Vps291/Vps29L152E.GFP adults show decreased climbing activity; electroretinogram readings show decreased ON transients.

      (Ye et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Vps291
      (Ye et al., 2020)
      Vps29ywing2+
      (Ye et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)