FB2026_02 , released June 18, 2026
Allele: Dmel\unc-4DBD
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General Information
Symbol
Dmel\unc-4DBD
Species
D. melanogaster
Name
FlyBase ID
FBal0360288
Feature type
allele
Associated gene
Dmel\unc-4
Associated Insertion(s)
TI{2A-GAL4(DBD)::Zip-}unc-4DBD
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lacin et al., 2020)
Mutagen
phiC31 integrase
(Lacin et al., 2020)
Progenitor genotype
TI{TI}unc-4FRT
(Lacin et al., 2020)
Associated Insertion(s)
TI{2A-GAL4(DBD)::Zip-}unc-4DBD
Cytology
Description

2A-GAL4(DBD)::Zip- is introduced into the attP site in the TI{TI}unc-4FRT progenitor. The Trojan insertion introduces a stop codon, truncating the unc-4 protein after its first exon.

(Lacin et al., 2020)
Allele components
Component
Use(s)
Inserted element
TI{2A-GAL4(DBD)::Zip-}
Encoded product / tool
GAL4(DBD)::Zip-
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      unc-4DBD adults exhibit erect wings and impaired grooming (due to lack of coordination among legs); also they fail in executing three-leg rubbing and climbing/walking (due to falling or being extremely slow).

      Adult unc-4DBD femoral chordotonal organ neurons exhibit displaced cell bodies across the femur and disrupted dendritic projections.

      unc-4DBD adults exhibit disorganized and smaller motor neurons 1-5.

      (Lacin et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      unc-4DBD is partially rescued by Hsim\VP16AD.Tub/unc-4UAS.cLa/Scer\GAL4unc-4-DBD

      (Lacin et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      unc-4DBD
      (Lacin et al., 2020)
      uncDBD
      (Lacin et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)