FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\armH47R.UAS.Tag:HA
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General Information
Symbol
Dmel\armH47R.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0360528
Feature type
allele
Associated gene
Dmel\arm
Associated Insertion(s)
Carried in Construct
P{UAS-arm.H47R.HA}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(White et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(White et al., 2018)
Mutagen
in vitro construct
(White et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-arm.H47R.HA}
Cytology
Description

UASt regulatory sequences drive expression of mutant arm cDNA (clone LD23131), tagged with Tag:HA at the C-terminus. Contains an amino acid substitution equivalent to the H36R variant identified in the human GSK3β ortholog in several cancers. (FlyBase curator comment: the mutation in the arm gene is given as H42R in FBrf0240580, however analysis of the release 6.37 annotated gene model indicates the change to be H47R).

(White et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
arm
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:1,896,645..1,896,645 [-]
Nucleotide change:

A1896645G

Amino acid change:

H47R | arm-PA; H47R | arm-PB; H47R | arm-PC; H47R | arm-PD; H47R | arm-PE; H47R | arm-PF

Reported amino acid change:

H42R

Comment:

Analogous H36R mutation in human CTNNB1 implicated in cancer; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(White et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA
      (White et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (White et al., 2018)
      CTNNB1:p.His36Arg
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      CTNNB1:p.His29Arg
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      armH42R.UAS.Tag:HA
      armH47R.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)