FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Rho1N19.Y189.UASp.CRY2.mCh
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General Information
Symbol
Dmel\Rho1N19.Y189.UASp.CRY2.mCh
Species
D. melanogaster
Name
FlyBase ID
FBal0361145
Feature type
allele
Associated gene
Dmel\Rho1
Associated Insertion(s)
Carried in Construct
P{UASp-CRY2-mCherry-Rho1.N19.Y189}
Key Links
Transgenic product class
dominant_negative_variant
(Guo et al., 2022)
missense_variant
(Guo et al., 2022)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Guo et al., 2022)
missense_variant
(Guo et al., 2022)
Mutagen
in vitro construct
(Guo et al., 2022, Eritano et al., 2020)
Progenitor genotype
Carried in construct
P{UASp-CRY2-mCherry-Rho1.N19.Y189}
Cytology
Description

UASp regulatory sequences drive expression of a dominant-negative form of Rho1 (contains amino acid substitution T19N) that also contains a C189Y substitution in its membrane targeting signal, tagged at the N-terminal end with CRY2(PHR) and mCherry.

(Guo et al., 2022)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Rho1
Tagged with
CRY2(PHR)
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In stage 6 embryos expressing Rho1N19.Y189.UASp.CRY2.mCh under the control of Scer\GAL4VP16.mat.αTub67C, light-induced cortical recruitment of Rho1N19.Y189.UASp.CRY2.mCh prevents cephalic furrow formation.

      (Eritano et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rho1N19.Y189.UASp.CRY2.mCh
      Name Synonyms
      Secondary FlyBase IDs
        References (5)