FB2026_02 , released June 18, 2026
Allele: Dmel\Tgs1R2
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General Information
Symbol
Dmel\Tgs1R2
Species
D. melanogaster
Name
FlyBase ID
FBal0361148
Feature type
allele
Associated gene
Dmel\Tgs1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Maccallini et al., 2020)
Mutagen
CRISPR/Cas9
(Maccallini et al., 2020)
Progenitor genotype
Cytology
Description

Frameshift mutation in the Tgs1 coding sequence, resulting in an early stop codon. A dicistronic locus encodes both the moi (upstream) and Tgs1 (downstream) open reading frames (ORFs). The lethality of the Tgs1R2 mutation is rescued by a transgene containing only the Tgs1 ORF, and is not rescued by a transgene containing only the moi ORF.

(Maccallini et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tgs1R2
      dTgs1R2
      (Maccallini et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)