FB2026_03 , released September 17, 2026
Allele: Dmel\Nup107D364N
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General Information
Symbol
Dmel\Nup107D364N
Species
D. melanogaster
Name
FlyBase ID
FBal0362043
Feature type
allele
Associated gene
Dmel\Nup107
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Levi et al., 2020)
gene targeting by homologous recombination
(Levi et al., 2020)
Progenitor genotype
Cytology
Description

D364N amino acid replacement (G1090A nucleotide substitution) within Nup107, a change that is equivalent to the D447N mutation in the human NUP107 ortholog, a variant associated with XX-gonadal dysgenesis. Two silent mutations (C to T and T to C nucleotide substitutions) have also been introduced.

(Levi et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:10,734,856..10,734,856 [-]
Nucleotide change:

G10734856A

Reported nucleotide change:

GAT>AAT

Amino acid change:

D364N | Nup107-PA

Reported amino acid change:

D364N

Comment:

Analogous D447N mutation in human NUP107 implicated in ovarian dysgenesis 6. Two nearby silent mutations were also introduced.

(Levi et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  ovarian dysgenesis 6
      CEA
      (Levi et al., 2020)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Levi et al., 2020)
      NUP107:p.Asp447Asn
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      NUP107:p.Asp418Asn
      Associated human disease model(s)
      External database links
      ClinVar: NUP107_559482
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Nup107D364N
      (Levi et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)