FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mettl5Δ2AA
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General Information
Symbol
Dmel\Mettl5Δ2AA
Species
D. melanogaster
Name
FlyBase ID
FBal0362131
Feature type
allele
Associated gene
Dmel\Mettl5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Leismann et al., 2020)
Progenitor genotype
Cytology
Description

A deletion of six bp from base pair 104 to 109, resulting in a two amino acid deletion just upstream the predicted methyltransferase signatures (at positions 36 and 37). These two amino acids are conserved from flies to human.

(Leismann et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:19,265,061..19,265,066 [+]
Comment:

In frame 6bp deletion leading to the deletion of two Ala residues at positions 36 and 37, PHIAACMAH to PHICMAH.

(Leismann et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mettl5Δ2AA/Mettl5Δ2AA adults exhibit a mild angular deviation from the walking tracks.

      (Leismann et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mettl5Δ2AA
      (Leismann et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)