FlyBase Allele Report: Dmel\Mon1[156]

General Information

Symbol

Dmel\Mon1¹⁵⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0362183

Feature type

allele

Associated gene

Dmel\Mon1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: Q157term.

(Basargekar et al., 2020)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:4,851,219..4,851,219 [+]

Nucleotide change:

C4851219T

Amino acid change:

Q157term | Mon1-PA

Reported amino acid change:

Q157term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Basargekar et al., 2020)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior (with Df(2L)Exel9062)

(Basargekar et al., 2020)

abnormal locomotor behavior (with Mon1^Δ181)

(Basargekar et al., 2020)

lethal (with Mon1^Δ181)

(Basargekar et al., 2020)

short lived (with Df(2L)Exel9062)

(Basargekar et al., 2020)

short lived (with Mon1^Δ129)

(Basargekar et al., 2020)

short lived (with Mon1^Δ181)

(Basargekar et al., 2020)

Phenotype Manifest In

muscle cell of A1-7 lateral longitudinal muscle 1 | larval stage (with Df(2L)Exel9062)

(Basargekar et al., 2020)

muscle cell of A1-7 lateral longitudinal muscle 1 | larval stage (with Mon1^Δ181)

(Basargekar et al., 2020)

NMJ bouton | increased number | larval stage (with Df(2L)Exel9062)

(Basargekar et al., 2020)

NMJ bouton | increased number | larval stage (with Mon1^Δ181)

(Basargekar et al., 2020)

Detailed Description

Statement

Reference

Mon1^Δ181/Mon1¹⁵⁶ or Mon1¹⁵⁶/Df(2L)Exel9062 larvae exhibit defects in synaptic morphology (the boutons are larger and odd shaped with many supernumerary or satellite boutons) and adults exhibit a decrease in their climbing ability.

(Basargekar et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Mon1^Δ181/Mon1¹⁵⁶ is rescued by Scer\GAL4^elav-C155/Mon1^UAS.Tag:HA

(Basargekar et al., 2020)

Mon1^Δ181/Mon1¹⁵⁶ is rescued by Scer\GAL4^elav.PU/Mon1^UAS.Tag:HA

(Basargekar et al., 2020)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

The Mon1¹⁵⁶ mutation was identified as an amber mutation within the Mon1 coding sequence on the chromosome carrying the pog¹ mutant allele. Lethality of the chromosome in transheterozygous combination with the Mon1^Δ181 mutant can be rescued by overexpression of Mon1, confirming that Mon1 gene function is disrupted by the Mon1¹⁵⁶ mutation. However, the homozygous lethality of this chromosome cannot be rescued by overexpression of Mon1, indicating that the chromosome also carries a second site mutation that contributes to the lethality of the chromosome. FlyBase curator comment: it is not yet clear whether the 'poor gastrulation' phenotype for which the unmapped pog¹ mutation was named is due to disrupted function of the Mon1 gene (caused by the Mon1¹⁵⁶ mutation) and/or due to the second site mutation on the chromosome, thus the pog¹ allele and parent pog gene have been kept as separate entities in FlyBase from Mon1¹⁵⁶ and Mon1 until more information becomes available [date: 200812].

(Basargekar et al., 2020)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dmon1¹⁵⁶

(Basargekar et al., 2020)

Mon1¹⁵⁶

Name Synonyms

Secondary FlyBase IDs

References (1)

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