FlyBase Allele Report: Dmel\lap[A.UAS]

General Information

Symbol

Dmel\lap^A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0362414

Feature type

allele

Associated gene

Dmel\lap

Associated Insertion(s)

Carried in Construct

P{UAS-lap.A}

Key Links

Transgenic product class

cDNA

(Yu et al., 2020)

wild_type

(Yu et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Yu et al., 2020)

wild_type

(Yu et al., 2020)

Mutagen

in vitro construct

(Yu et al., 2020)

Progenitor genotype

Carried in construct

P{UAS-lap.A}

Cytology

Description

UASt regulatory sequences drive expression of the lap A isoform (isolated from the RH47395 cDNA clone).

(Yu et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

lap

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Yu et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

lap^A.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

lap^A.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor | partially of abnormal locomotor behavior | RU486 conditional phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lap^A.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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