Expression of Sirt1^VDRC.cUa under the control of Scer\GAL4^Hand.PU leads to significantly reduced heart period, diastolic period, systolic period, and fractional shortening whereas it leads to significantly increased diastolic dysfunction index when compared to control adults. Exercise training significantly enhances these hearth function phenotypes, except the systolic period phenotype.

Expression of Sirt1^VDRC.cUa under the control of Scer\GAL4^Hand.PU significantly decreases the climbing index of 5- and 7- week-old flies (but not of 1- or 3-week-old flies) compared to controls. Exercise improves the climbing index of 5-week-old (but not of 1-, 3- or 7-week-old) flies that express Sirt1^VDRC.cUa under the control of Scer\GAL4^Hand.PU and it improves the short lifespan of flies that express Sirt1^VDRC.cUa under the control of Scer\GAL4^Hand.PU compared to control adults.