FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ninaEP37H.UAS.cXa
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General Information
Symbol
Dmel\ninaEP37H.UAS.cXa
Species
D. melanogaster
Name
UAS construct a of Xu
FlyBase ID
FBal0364820
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
P{UAS-Rh1P37H.X}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Xu et al., 2020)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Xu et al., 2020)
Mutagen
in vitro construct
(Xu et al., 2020)
Progenitor genotype
Carried in construct
P{UAS-Rh1P37H.X}
Cytology
Description

UASt regulates expression of ninaE cDNA (RH01460) containing the P37H mutation, the equivalent of mammalian Rhodopsin[P23H], which is the most common genetic mutation associated with autosomal dominant retinitis pigmentosa.

(Xu et al., 2020)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ninaE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3R:19,887,857..19,887,858 [-]
Reported amino acid change:

P37H

Comment:

Analogous P23H mutation in human RHO implicated in retinitis pigmentosa 4; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Xu et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  retinal disease
      CEA
      (Xu et al., 2020)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  retinal disease
      is ameliorated by sordd1UAS.cXa
      (Xu et al., 2020)
      is ameliorated by sordd2UAS.cXa
      (Xu et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Xu et al., 2020)
      RHO:p.Pro23His
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: RHO_13013
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing ninaEP37H.UAS.cXa under the control of Scer\GAL4GMR.PU leads to a glossy eye phenotype.

      (Xu et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ninaEP37H.UAS.cXa
      Name Synonyms
      UAS construct a of Xu
      Secondary FlyBase IDs
        References (2)