FB2026_03 , released September 17, 2026
Allele: Dmel\wCopyCat
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General Information
Symbol
Dmel\wCopyCat
Species
D. melanogaster
Name
FlyBase ID
FBal0364896
Feature type
allele
Associated gene
Dmel\w
Associated Insertion(s)
TI{TI}wCopyCat
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(López Del Amo et al., 2020)
gene targeting by homologous recombination
(López Del Amo et al., 2020)
Progenitor genotype
Associated Insertion(s)
TI{TI}wCopyCat
Cytology
Description

A 'CopyCat' sequence cassette composed of 1. a snRNA:U6:96Aa promoter driving expression of a gRNA that targets w, 2. a Blan\blFP-Y3mNeonGreen.3xP3 marker, 3. homology arms to w at both 5' and 3' ends, has been inserted into the endogenous e locus. Used as part of a gene drive system; when combined with a source of Cas9, the 'CopyCat' sequence cassette can copy itself onto the w locus on the opposing chromosome by homology-directed repair (using the w homology arms present at the 5' and 3' ends of the cassette).

(López Del Amo et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      wCopyCat
      Name Synonyms
      Secondary FlyBase IDs
        References (1)