FB2026_02 , released June 18, 2026
Allele: Dmel\Rox8KO
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General Information
Symbol
Dmel\Rox8KO
Species
D. melanogaster
Name
FlyBase ID
FBal0365494
Feature type
allele
Associated gene
Dmel\Rox8
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Guo et al., 2020)
Progenitor genotype
Cytology
Description

Lesion (deletion, along with replacement of a 16bp sequence with random sequence) within Rox8, near the start of the open reading frame. This results in a frameshift that generates a short random protein immediately after the first methionine.

(Guo et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:24,045,230..24,045,661 [-]
Inserted_sequence:

TCGCGAGACATCATGG

(Guo et al., 2020)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  cancer
      modeled by Ras85DV12.UAS, l(2)gl4
      (Guo et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rox8KO eye-antennal disc clones are larger than controls.

      Rox8KO midguts are larger and show increased mitotic index.

      (Guo et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rox8KO
      (Guo et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)