FlyBase Allele Report: Hsap\DNM1L[S616A.UAS.Tag:MYC,Tag:polyHis]

General Information

Symbol

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}

Species

H. sapiens

Name

FlyBase ID

FBal0365609

Feature type

allele

Associated gene

Hsap\DNM1L

Associated Insertion(s)

Carried in Construct

P{UAS-hDNM1L.S616A.MYC.His6}

Key Links

Transgenic product class

missense_variant

(Han et al., 2020)

polypeptide_post_translational_processing_variant

(Han et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Han et al., 2020)

polypeptide_post_translational_processing_variant

(Han et al., 2020)

Mutagen

in vitro construct

(Han et al., 2020)

Progenitor genotype

Carried in construct

P{UAS-hDNM1L.S616A.MYC.His6}

Cytology

Description

UAS regulatory sequences drive expression of mutant dephosphorylation-mimic Hsap\DNM1L isoform 1 cDNA (contains the amino acid replacement S616A) tagged with Tag:MYC and 6xTag:polyHis.

(Han et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Tagged with

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a suppressor | partially of visible | adult stage phenotype of Pink1^B9

(Han et al., 2020)

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a suppressor | partially of visible | adult stage phenotype of Atg7^d14/Atg7^d77, Pink1^B9

(Han et al., 2020)

NOT Suppressor of

Statement

Reference

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a non-suppressor of increased cell death | adult stage phenotype of Pink1^B9

(Han et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a suppressor of adult thorax phenotype of Pink1^B9

(Han et al., 2020)

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a suppressor | partially of adult thorax phenotype of Atg7^d14/Atg7^d77, Pink1^B9

(Han et al., 2020)

NOT Suppressor of

Statement

Reference

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a non-suppressor of indirect flight muscle cell phenotype of Pink1^B9

(Han et al., 2020)

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a non-suppressor of mitochondrial crista | adult stage phenotype of Pink1^B9

(Han et al., 2020)

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a non-suppressor | partially of adult thorax phenotype of Atg7^d14/Atg7^d77, Pink1^B9

(Han et al., 2020)

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a non-suppressor of mitochondrion | adult stage phenotype of Atg7^d14/Atg7^d77, Pink1^B9

(Han et al., 2020)

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}/Scer\GAL4^Mhc.PU is a non-suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Han et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\DNM1L^{S616A.UAS.Tag:MYC,Tag:polyHis}

hDrp1^S616A

(Jin et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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