FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SarmE1170A
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General Information
Symbol
Dmel\SarmE1170A
Species
D. melanogaster
Name
FlyBase ID
FBal0367056
Feature type
allele
Associated gene
Dmel\Sarm
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Hsu et al., 2021)
gene targeting by homologous recombination
(Hsu et al., 2021)
Progenitor genotype
TI{ywing2+}Sarmywg2+
(Hsu et al., 2021)
Cytology
Description

The TI{ywing2+} cassette in TI{ywing2+}Sarmywg2+ has been replaced with sequence that reconstitutes a complete Sarm transcription unit carrying a E1170A amino acid substitution. This mutation is in a conserved residue equivalent to the E642 residue previously shown to be critical for NAD[+] hydrolase activity in the orthologous human gene.

(Hsu et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SarmE1170A
      dsarmE1170A
      (Hsu et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)