FlyBase Allele Report: Dmel\α-PheRS[Cys.UAS]

General Information

Symbol

Dmel\α-PheRS^Cys.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0367266

Feature type

allele

Associated gene

Dmel\α-PheRS

Associated Insertion(s)

Carried in Construct

M{UAS-α-PheRS.Cys}

Key Links

Transgenic product class

missense_variant

(Ho et al., 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Ho et al., 2021)

Mutagen

in vitro construct

(Ho et al., 2021)

Progenitor genotype

Carried in construct

M{UAS-α-PheRS.Cys}

Cytology

Description

UASt regulatory sequences drive expression of α-PheRS cDNA containing the Tyr412Cys and Phe438Cys mutations.

(Ho et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

α-PheRS

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | oogenesis | somatic clone, with Scer\GAL4^Act.PU

(Ho et al., 2021)

increased occurrence of cell division | larval stage, with Scer\GAL4^en-e16E

(Ho et al., 2021)

increased occurrence of cell division | oogenesis | somatic clone, with Scer\GAL4^Act.PU

(Ho et al., 2021)

increased size | oogenesis | somatic clone, with Scer\GAL4^Act.PU

(Ho et al., 2021)

Phenotype Manifest In

follicle cell | somatic clone, with Scer\GAL4^Act.PU

(Ho et al., 2021)

wing disc posterior compartment, with Scer\GAL4^en-e16E

(Ho et al., 2021)

Detailed Description

Statement

Reference

The clonal expression of α-PheRS^Cys.UAS under the control of Scer\GAL4^Act.PU leads to larger follicle cell clones with increased mitotic index.

(Ho et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has increased occurrence of cell division | oogenesis | somatic clone phenotype, non-enhanceable by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has increased size | oogenesis | somatic clone phenotype, non-enhanceable by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has increased cell number | oogenesis | somatic clone phenotype, non-enhanceable by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

NOT suppressed by

Statement

Reference

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has increased occurrence of cell division | somatic clone | oogenesis phenotype, non-suppressible by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has increased size | somatic clone | oogenesis phenotype, non-suppressible by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has increased cell number | somatic clone | oogenesis phenotype, non-suppressible by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has follicle cell | somatic clone phenotype, non-enhanceable by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

NOT suppressed by

Statement

Reference

α-PheRS^Cys.UAS, Scer\GAL4^Act.PU has follicle cell | somatic clone phenotype, non-suppressible by β-PheRS^UAS.cLa, Scer\GAL4^Act.PU

(Ho et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99909

w^*; M{UAS-α-PheRS.Cys}ZH-86Fb

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

α-PheRS^Cys.UAS

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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