FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\htlλ.lexAop
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General Information
Symbol
Dmel\htlλ.lexAop
Species
D. melanogaster
Name
FlyBase ID
FBal0368227
Feature type
allele
Associated gene
Dmel\htl
Associated Insertion(s)
Carried in Construct
P{lexAop-htl.λ.D}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Dong et al., 2021)
Progenitor genotype
Carried in construct
P{lexAop-htl.λ.D}
Cytology
Description

13lexAop2 regulatory sequences drive expression of a constitutively active form of htl in which the extracellular domain of htl has been replaced with the dimerization domain of the bacteriophage λ cI repressor.

(Dong et al., 2021)
Allele components
Component
Use(s)
Regulatory region(s)
lexAop
Encoded product / tool
htl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing htlλ.lexAop under the control of Ecol\lexAGAD.repo induces a decreased number of neurons generated per neuroblast; neuroblasts show decrease proliferation.

      (Dong et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      htlλ.lexAop/Ecol\lexAGAD.repo is a non-suppressor of neuroblast | larval stage phenotype of Scer\GAL4nab, ciNIG.2125R

      (Dong et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      htlλ.lexAop
      Name Synonyms
      Secondary FlyBase IDs
        References (1)