FB2026_02 , released June 18, 2026
Allele: Dmel\Lectin-galC1fs
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General Information
Symbol
Dmel\Lectin-galC1fs
Species
D. melanogaster
Name
FlyBase ID
FBal0368230
Feature type
allele
Associated gene
Dmel\Lectin-galC1
Associated Insertion(s)
TI{TI}Lectin-galC1fs
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Bhimreddy et al., 2021)
Mutagen
CRISPR/Cas9
(Bhimreddy et al., 2021)
gene targeting by homologous recombination
(Bhimreddy et al., 2021)
Progenitor genotype
Associated Insertion(s)
TI{TI}Lectin-galC1fs
Cytology
Description

Substitutions and deletions lead to a frame-shift, resulting in a stop codon and 70-peptide fragment.

(Bhimreddy et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2L:19,417,464..19,417,471 [+]
Inserted_sequence:

CCTCGA

Comment:

Deletion of 8 bases just after the ATG and insertion of 6 bases (CCTCGA) leads to a frameshift.

(Bhimreddy et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lectin-galC1fs/Lectin-galC1fs and Lectin-galC1fs/Df(2L)Exel6043 wandering third instar larvae show shorter peristaltic waves during crawling and shorter rolling time in righting assays. NMJs show increased synapse density and decreased synaptic vesicle density within boutons, particularly closer to the synapse. Electrophysiological recording at the NMJ show increased EJC amplitude and increased mEJC frequency; and decreased EJC amplitudes immediately following high frequency stimulation train initiation, with slower recovery rates.

      (Bhimreddy et al., 2021)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LGC1fs
      (Bhimreddy et al., 2021)
      Lectin-galC1fs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)