FlyBase Allele Report: Dmel\Egfrap[LS]

General Information

Symbol

Dmel\Egfrap^LS

Species

D. melanogaster

Name

FlyBase ID

FBal0369939

Feature type

allele

Associated gene

Dmel\Egfrap

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Soler Beatty et al., 2021)

Mutagen

CRISPR/Cas9

(Soler Beatty et al., 2021)

Progenitor genotype

Cytology

Description

Deletion of 7 base pairs, resulting in a frame-shift generating a stop codon 14 amino acids after the shift, thereby eliminating both the long (Egfrap-RA) and short (Egfrap-RB) isoforms of Egfrap.

(Soler Beatty et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by Ras85D^V12.UAS

(Soler Beatty et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Soler Beatty et al., 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Egfrap^LS, Ras85D^V12.UAS, Scer\GAL4^ap.PU has neoplasia | third instar larval stage phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Enhancer of

Statement

Reference

Egfrap^LS/Egfrap^LS is an enhancer of neoplasia | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Egfrap^LS/Egfrap^LS is an enhancer of neoplasia | third instar larval stage phenotype of PVRAP^HMJ23233, Ras85D^V12.UAS, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Egfrap^LS, Ras85D^V12.UAS, Scer\GAL4^ap.PU has wing disc dorsal compartment | third instar larval stage phenotype, enhanceable by PVRAP^HMJ23233, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Enhancer of

Statement

Reference

Egfrap^LS/Egfrap^LS is an enhancer of wing disc dorsal compartment | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^ap.PU

(Soler Beatty et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

EGFRAP^L/S

(Soler Beatty et al., 2021)

Egfrap^LS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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