FlyBase Allele Report: Hsap\TNPO3[UAS.Tag:HA]

General Information

Symbol

Hsap\TNPO3^UAS.Tag:HA

Species

H. sapiens

Name

FlyBase ID

FBal0369962

Feature type

allele

Associated gene

Hsap\TNPO3

Associated Insertion(s)

Carried in Construct

P{UAS-hTNPO3.HA}

Key Links

Transgenic product class

cDNA

(Blázquez-Bernal et al., 2021)

wild_type

(Blázquez-Bernal et al., 2021)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Blázquez-Bernal et al., 2021)

wild_type

(Blázquez-Bernal et al., 2021)

Mutagen

in vitro construct

(Blázquez-Bernal et al., 2021)

Progenitor genotype

Carried in construct

P{UAS-hTNPO3.HA}

Cytology

Description

UASt regulatory sequences drive expression of a wild-type Hsap\TNPO3 cDNA. The coding sequence is tagged at the N-terminal end with Tag:HA.

(Blázquez-Bernal et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\TNPO3

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult abdominal segment 4, with Scer\GAL4^Toll-6-D42

(Blázquez-Bernal et al., 2021)

indirect flight muscle cell | adult stage, with Scer\GAL4^Mhc.PW

(Blázquez-Bernal et al., 2021)

myotube | adult stage, with Scer\GAL4^Toll-6-D42

(Blázquez-Bernal et al., 2021)

Detailed Description

Statement

Reference

Expression of Hsap\TNPO3^UAS.Tag:HA under the control of Scer\GAL4^Mhc.PW leads to a decrease in climbing activity and to a progressive decrease in indirect flight muscle area. Expression under the control of Scer\GAL4^Toll-6-D42 leads to a decrease in climbing activity, ta a decrease in flight ability and to thinner abdominal segment muscle fibers in 15-days old fibers.

(Blázquez-Bernal et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsap\TNPO3^UAS.Tag:HA

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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