FlyBase Allele Report: Dmel\Hinfp[2]

General Information

Symbol

Dmel\Hinfp²

Species

D. melanogaster

Name

FlyBase ID

FBal0370080

Feature type

allele

Associated gene

Dmel\Hinfp

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Nirala et al., 2021)

Progenitor genotype

Cytology

Description

31 bp deletion leading to a premature stop at amino acid 54.

(Nirala et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:625,970..626,001 [+]

Comment:

A 31 bp deletion (tgcagGGGAAGCTGGAGTGCGATCTGCATCC) leading to a premature stop at amino acid 22.

(Nirala and Ip, 2021.10.27)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Hinfp² mutants exhibit decreased frequency of mitosis in the larval midgut; the larval, pupal and adult midgut, as well as the larval wing disc, exhibit increased DNA damage.

Hinfp² midgut clones induced during adulthood are overgrown, particularly in the middle region of the midgut, and exhibit increased DNA damage. Similarly, follicle cell clones exhibit DNA damage.

(Nirala et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hinfp² has increased mortality during development phenotype, suppressible | partially by Scer\GAL4^Tub.PU/His1:CG33864^{UAS.ORF.Tag:HA}

(Nirala et al., 2021)

Hinfp² has abnormal DNA repair | adult stage phenotype, suppressible by Scer\GAL4^Tub.PU/His1:CG33864^{UAS.ORF.Tag:HA}

(Nirala et al., 2021)

NOT suppressed by

Statement

Reference

Hinfp² has increased mortality during development phenotype, non-suppressible by Scer\GAL4^Tub.PU/His4:CG31611^{UAS.ORF.Tag:HA}

(Nirala et al., 2021)

Hinfp² has increased mortality during development phenotype, non-suppressible by msn^UAS.Tag:HA/Scer\GAL4^Tub.PU

(Nirala et al., 2021)

Other

Statement

Reference

Hinfp², His1:CG33864^{UAS.ORF.Tag:HA}, Scer\GAL4^Tub.PU has partially lethal - majority live phenotype

(Nirala et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hinfp² has adult gut phenotype, suppressible by Scer\GAL4^Tub.PU/His1:CG33864^{UAS.ORF.Tag:HA}

(Nirala et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Hinfp² is partially rescued by Scer\GAL4^Tub.PU/Hinfp^{UAS.ORF.GW.Tag:HA}

(Nirala et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hinfp²

(Nirala et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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