FB2026_03 , released September 17, 2026
Allele: Dmel\Fancd2K595R
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General Information
Symbol
Dmel\Fancd2K595R
Species
D. melanogaster
Name
FlyBase ID
FBal0370222
Feature type
allele
Associated gene
Dmel\Fancd2
Associated Insertion(s)
TI{TI}Fancd2K595R
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Clay et al., 2021)
gene targeting by homologous recombination
(Clay et al., 2021)
Progenitor genotype
Associated Insertion(s)
TI{TI}Fancd2K595R
Cytology
Description

The conserved monoubiquitination site within endogenous Fancd2 (K595) has been mutated to an arginine.

(Clay et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:20,813,845..20,813,845 [-]
Nucleotide change:

A20813845G

Amino acid change:

K595R | Fancd2-PA

Reported amino acid change:

K595R

Comment:

The conserved monoubiquitination site within endogenous Fancd2 (K595) has been mutated to an arginine via a two-step process. The nucleotide change was inferred from the amino acid change. It's not clear if any other nucleotide change is associated with this mutation.

(Clay et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Fanconi anemia complementation group D2
      CEC
      (Clay et al., 2022)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fancd2K595R
      fancd2K595R
      (Clay et al., 2022, Clay et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)