FlyBase Allele Report: Hsap\HOXA9::Hsap\NUP98[ey.PG]

General Information

Symbol

Hsap\HOXA9::Hsap\NUP98^ey.PG

Species

H. sapiens

Name

eyeless promoter construct of Gavory

FlyBase ID

FBal0370730

Feature type

allele

Associated gene

Hsap\HOXA9::Hsap\NUP98

Associated Insertion(s)

Carried in Construct

P{ey-NA9.G}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Gavory et al., 2021)

Progenitor genotype

Carried in construct

P{ey-NA9.G}

Cytology

Description

The ey-hsp70 enhancer-promoter cassette regulates expression of the Hsap\HOXA9::Hsap\NUP98 fusion gene.

(Gavory et al., 2021)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

Hsap\HOXA9::Hsap\NUP98

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Gavory et al., 2021)

NUP98/HOXA9_fusion

(FlyBase curators, 2019-)

Variants Synonym(s)

t(7;11)(p15;p15) NUP98/HOXA9

Associated human disease model(s)

acute myeloid leukemia, NUP98-HOXA9 fusion

External database links

Comments concerning this variant

Phenotypic Data

Phenotypic Class

decreased size | adult stage

(Gavory et al., 2021)

visible | adult stage

(Gavory et al., 2021)

Phenotype Manifest In

eye

(Gavory et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by CG6583[+]/CG6583^E-1012

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by CG6583[+]/CG6583^E-326

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by CG6583[+]/CG6583^E-326

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by gpp[+]/gpp^E-1750

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by gpp[+]/gpp^E-1750

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by E(Pc)[+]/E(Pc)^E-1768

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by E(Pc)[+]/E(Pc)^E-1768

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by CG6583^E-230/CG6583[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by CG6583[+]/CG6583^E-1012

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by CG6583^E-230/CG6583[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by gpp[+]/gpp^E-3000

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by gpp[+]/gpp^E-3000

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by Rae1[+]/Rae1^E-558

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by Rae1[+]/Rae1^E-558

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by Rae1[+]/Rae1^E-1896

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by Rae1[+]/Rae1^E-1896

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by E(Pc)^E-4112/E(Pc)[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by E(Pc)^E-4112/E(Pc)[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by emb[+]/emb^E-159

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by emb[+]/emb^E-159

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by emb[+]/emb^E-1836

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by emb[+]/emb^E-1836

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by Rae1[+]/Rae1^E-992

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by emb[+]/emb^E-1854

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by emb[+]/emb^E-1854

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by emb[+]/emb^E-379

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by emb[+]/emb^E-379

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by Rae1[+]/Rae1^E-992

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, enhanceable by CG6583^E-1448/CG6583[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, enhanceable by CG6583^E-1448/CG6583[+]

(Gavory et al., 2021)

Suppressed by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by eIF3b^S-1820/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by eIF3b^S-2265/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by grh^S-159/grh[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by eIF3b^S-4212/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by eIF3b^S-2265/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by eIF3b^S-4212/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by grh^S-159/grh[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by hth^S-195/hth[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by hth^S-195/hth[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by tara^S-1902/tara[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by Mmp2^S-2288/Mmp2[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by Mmp2[+]/Mmp2^S-2713

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by tara^S-1192/tara[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by tara^S-1902/tara[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by tara^S-1192/tara[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by Mmp2[+]/Mmp2^S-2713

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has decreased size | adult stage phenotype, suppressible | partially by Mmp2^S-2288/Mmp2[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has visible | adult stage phenotype, suppressible | partially by eIF3b^S-1820/eIF3b[+]

(Gavory et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by CG6583[+]/CG6583^E-1012

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by gpp[+]/gpp^E-1750

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by E(Pc)[+]/E(Pc)^E-1768

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by CG6583^E-230/CG6583[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by gpp[+]/gpp^E-3000

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by Rae1[+]/Rae1^E-558

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by Rae1[+]/Rae1^E-1896

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by Rae1[+]/Rae1^E-992

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by E(Pc)^E-4112/E(Pc)[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by emb[+]/emb^E-159

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by emb[+]/emb^E-1836

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by emb[+]/emb^E-1854

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by emb[+]/emb^E-379

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by CG6583^E-1448/CG6583[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, enhanceable by CG6583[+]/CG6583^E-326

(Gavory et al., 2021)

Suppressed by

Statement

Reference

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by eIF3b^S-1820/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by eIF3b^S-2265/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by eIF3b^S-4212/eIF3b[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by grh^S-159/grh[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by hth^S-195/hth[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by tara^S-1902/tara[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by Mmp2[+]/Mmp2^S-2713

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by tara^S-1192/tara[+]

(Gavory et al., 2021)

Hsap\HOXA9::Hsap\NUP98^ey.PG has eye phenotype, suppressible | partially by Mmp2^S-2288/Mmp2[+]

(Gavory et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\HOXA9::Hsap\NUP98^ey.PG

Name Synonyms

eyeless promoter construct of Gavory

Secondary FlyBase IDs

References (2)

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