FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eIF3bS-4212
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General Information
Symbol
Dmel\eIF3bS-4212
Species
D. melanogaster
Name
FlyBase ID
FBal0370736
Feature type
allele
Associated gene
Dmel\eIF3b
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Gavory et al., 2021)
Progenitor genotype
Cytology
Description

Frameshift mutation.

(Gavory et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:17,538,287..17,538,330 [+]
Inserted_sequence:

ACGC

Comment:

Net loss of 39 nucleotides (43bp deletion, 4bp insertion) leads to the loss of 14 amino acids (VSSWKVKEDTGFNM).

(Baril and Therrien, 2022.2.9)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  acute myeloid leukemia
      modeled by Hsap\HOXA9::Hsap\NUP98WT.UAS
      (Gavory et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      eIF3bS-4212/eIF3b[+] is a suppressor | partially of visible | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98ey.PG

      (Gavory et al., 2021)

      eIF3bS-4212/eIF3b[+] is a suppressor | partially of decreased size | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98ey.PG

      (Gavory et al., 2021)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      eIF3bS-4212/eIF3b[+] is a suppressor | partially of eye phenotype of Hsap\HOXA9::Hsap\NUP98ey.PG

      (Gavory et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SN2-6S-4212
      (Gavory et al., 2021)
      eIF3bS-4212
      Name Synonyms
      Secondary FlyBase IDs
        References (2)