FB2026_03 , released September 17, 2026
Allele: Dmel\Sf3b1H698D
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General Information
Symbol
Dmel\Sf3b1H698D
Species
D. melanogaster
Name
FlyBase ID
FBal0370797
Feature type
allele
Associated gene
Dmel\Sf3b1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Zhang et al., 2021)
Progenitor genotype
Cytology
Description

A point mutation (H698D, corresponding to human disease-associated residue H662) is introduced into endogenous Sf3b1.

(Zhang et al., 2021)

Amino acid replacement: H698D.

(Zhang et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
2L:570,719..570,721 [+]
Nucleotide change:

CAC570719GAT

Reported nucleotide change:

CAC?GAT

Amino acid change:

H698D | Sf3b1-PA; H698D | Sf3b1-PB

Reported amino acid change:

H698D

Comment:

Analogous mutation in human SF3B1 is associated with cancer.

(Zhang et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Zhang et al., 2021)
      SF3B1:p.His662Asp
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
        External database links
        Comments concerning this variant

        Disease model in flies has not been developed.

        (FlyBase curators, 2019-)
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Sf3b1H698D
        sf3b1-H698D
        (Zhang et al., 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)