FB2026_03 , released September 17, 2026
Allele: Dmel\InR74(HR)
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General Information
Symbol
Dmel\InR74(HR)
Species
D. melanogaster
Name
FlyBase ID
FBal0370902
Feature type
allele
Associated gene
Dmel\InR
Associated Insertion(s)
TI{TI}InR74(HR)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Yamamoto et al., 2021)
cre recombinase
(Yamamoto et al., 2021)
FLPase
(Yamamoto et al., 2021)
I-SceI
(Yamamoto et al., 2021)
Progenitor genotype
Associated Insertion(s)
TI{TI}InR74(HR)
Cytology
Description

Amino acid replacement: I1543F.

(Yamamoto et al., 2021)

The I1543F amino acid substitution has been introduced into endogenous InR.

(Yamamoto et al., 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,575,196..21,575,196 [-]
Nucleotide change:

A21575196T

Reported nucleotide change:

A?T

Amino acid change:

I1544F | InR-PA; I1544F | InR-PB; I1544F | InR-PC; I1544F | InR-PD

Reported amino acid change:

I1543F

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change. The reported position of the Valine is one off from the position in the reference sequence.

(Yamamoto et al., 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      InR74(HR)
      (Yamamoto et al., 2021)
      dInr74[HR]
      (Tatar et al., 2025)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)