FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry
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General Information
Symbol
Dmel\DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0373187
Feature type
allele
Associated gene
Dmel\Dronc
Associated Insertion(s)
TI{TI}DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Arthurton et al., 2020)
Progenitor genotype
TI{TI}DroncKO.FRT.Dronc.WT.GFP.APEX2.FRT.SunTag(Unk),Tag:HA,mCherry
(Arthurton et al., 2020)
Associated Insertion(s)
TI{TI}DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry
Cytology
Description

The FRT cassette present in the progenitor DroncKO.FRT.Dronc.WT.GFP.APEX2.FRT.SunTag(Unk),Tag:HA,mCherry allele has been excised, allowing the SunTag(Unk), Tag:HA and mCherry chimeric tag sequence to be expressed under the control of endogenous Dronc regulatory sequences.

(Arthurton et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry/DroncKO transheterozygous clones specifically generated in adult intestinal stem cells/enteroblasts (esg-positive), leads to sings of hyperplasia in the posterior midgut, with increased number and size of esg-positive progenitors (ISCs and EBs), and increased number of enterocytes.

      DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry/DroncKO transheterozygous clones specifically generated in adult enteroblasts (Su(H)-positive), leads to enlarged enteroblasts.

      (Arthurton et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Adult posterior midgut clones specifically generated in esg-positive progenitors (ISCs and EBs), and which both express NdsRNA.UAS.cUa under the control of Scer\GAL4esg.PU and are DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry/DroncKO transheterozygous show increased proportion of progenitors.

      (Arthurton et al., 2020)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      DroncKO.-FRT.SunTag(Unk),Tag:HA,mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (1)