FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CtnsKO
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General Information
Symbol
Dmel\CtnsKO
Species
D. melanogaster
Name
FlyBase ID
FBal0373208
Feature type
allele
Associated gene
Dmel\Ctns
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Jouandin et al., 2022)
Mutagen
CRISPR/Cas9
(Jouandin et al., 2022)
Progenitor genotype
Cytology
Description

Frameshift mutant causing a premature stop codon.

(Jouandin et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:23,055,866..23,055,872 [-]
Inserted_sequence:

AC

Comment:

Seven bases are deleted (TCGAAAT) and two bases are inserted (AC) causing a frameshift in the fourth exon of Ctns. This leads to early translation termination after the addition of 18 novel amino acids.

(Jouandin et al., 2022, Marelja and Jouandin, 2022.4.8)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CtnsKO homozygous larvae show a developmental delay. Adults die more quickly from starvation.

      CtnsKO larval fat body clones show a cell autonomous decrease in the number of autophagosomes under starvation conditions.

      (Jouandin et al., 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CtnsKO
      (Marelja and Jouandin, 2022.4.8)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)