FlyBase Allele Report: Dmel\aft[M32]

General Information

Symbol

Dmel\aft^M32

Species

D. melanogaster

Name

FlyBase ID

FBal0373466

Feature type

allele

Associated gene

Dmel\aft

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Haussmann et al., 2022)

Mutagen

P-element activity

(Haussmann et al., 2022)

Progenitor genotype

P{EP}aft^G6146

(Haussmann et al., 2022)

Cytology

Description

Imprecise excision of P{EP}aft^G6146, resulting in deletion of the 5' half of the coding region, including almost all of the catalytic methyltransferase domain.

(Haussmann et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Haussmann et al., 2022)

abnormal neurophysiology | third instar larval stage

(Haussmann et al., 2022)

fertile

(Haussmann et al., 2022)

viable

(Haussmann et al., 2022)

Phenotype Manifest In

embryonic/larval neuromuscular junction | third instar larval stage

(Haussmann et al., 2022)

NMJ bouton | decreased number | third instar larval stage

(Haussmann et al., 2022)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Cmtr1^13A, aft^M32 has decreased efficacy of long-term memory phenotype, suppressible by aft^UAS.Tag:FLAG/Scer\GAL4^Mef2.247

(Haussmann et al., 2022)

Cmtr1^13A, aft^M32 has decreased efficacy of long-term memory phenotype, suppressible by aft^UAS.Tag:FLAG/Scer\GAL4^{Mef2.247.Switch}

(Haussmann et al., 2022)

Other

Statement

Reference

Cmtr1^13A, aft^M32 has viable phenotype

(Haussmann et al., 2022)

Cmtr1^13A, aft^M32 has fertile phenotype

(Haussmann et al., 2022)

Cmtr1^13A, aft^M32 has decreased efficacy of short-term memory phenotype

(Haussmann et al., 2022)

Cmtr1^13A, aft^M32 has decreased efficacy of long-term memory phenotype

(Haussmann et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

aft^M32, Cmtr1^13A adults exhibit decreased climbing ability.

(Haussmann et al., 2022)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CMTr2^M32

(Haussmann et al., 2022)

aft^M32

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close