FlyBase Allele Report: Dmel\PIP5K59B[RNAi.UAS.L.cKa]

General Information

Symbol

Dmel\PIP5K59B^{RNAi.UAS.L.cKa}

Species

D. melanogaster

Name

FlyBase ID

FBal0373567

Feature type

allele

Associated gene

Dmel\PIP5K59B

Associated Insertion(s)

Carried in Construct

P{UAS-PIP5K59B.L.RNAi.K}

Key Links

Transgenic product class

RNAi_reagent

(Kumari et al., 2022)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Kumari et al., 2022)

Mutagen

in vitro construct

(Kumari et al., 2022)

Progenitor genotype

Carried in construct

P{UAS-PIP5K59B.L.RNAi.K}

Cytology

Description

UAS regulatory sequences drive expression of shRNA targeting the PIP5K59B 'L' isoform (corresponds to PJ).

(Kumari et al., 2022)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

PIP5K59B

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage, with Scer\GAL4^GMR.PF

(Kumari et al., 2022)

abnormal neurophysiology | adult stage, with Scer\GAL4^ninaE.PT

(Kumari et al., 2022)

abnormal neurophysiology | adult stage | dominant, with Scer\GAL4^ninaE.PT

(Kumari et al., 2022)

Phenotype Manifest In

retina, with Scer\GAL4^GMR.PF

(Kumari et al., 2022)

retina, with Scer\GAL4^ninaE.PT

(Kumari et al., 2022)

Detailed Description

Statement

Reference

Adults expressing PIP5K59B^{dsRNA.UAS.L.cKa} under the control of Scer\GAL4^GMR.PF or Scer\GAL4^ninaE.PT show decreased retinal electrical response to green light (decreased amplitude), compared to controls.

(Kumari et al., 2022)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

PIP5K59B^{RNAi.UAS.L.cKa}, Scer\GAL4^ninaE.PT is a suppressor | partially of visible | adult stage | progressive | light conditional phenotype of Gαq^Q203L.UAS, Scer\GAL4^ninaE.PT

(Kumari et al., 2022)

PIP5K59B^{RNAi.UAS.L.cKa}/Scer\GAL4^ninaE.PT is a suppressor of abnormal neurophysiology | dominant | adult stage phenotype of pnut^XP

(Kumari et al., 2022)

PIP5K59B^{RNAi.UAS.L.cKa}/Scer\GAL4^ninaE.PT is a suppressor of abnormal neurophysiology | adult stage phenotype of rdgB⁹

(Kumari et al., 2022)

Phenotype Manifest In

Suppressor of

Statement

Reference

PIP5K59B^{RNAi.UAS.L.cKa}/Scer\GAL4^GMR.PF is a suppressor | partially of ommatidium | light conditional phenotype of Gαq^Q203L.UAS, Scer\GAL4^ninaE.PT

(Kumari et al., 2022)

PIP5K59B^{RNAi.UAS.L.cKa}/Scer\GAL4^GMR.PF is a suppressor | partially of rhabdomere | light conditional | decreased number phenotype of Gαq^Q203L.UAS, Scer\GAL4^ninaE.PT

(Kumari et al., 2022)

PIP5K59B^{RNAi.UAS.L.cKa}/Scer\GAL4^ninaE.PT is a suppressor of retina phenotype of rdgB⁹

(Kumari et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PIP5K59B^{RNAi.UAS.L.cKa}

PIP5K59B^{dsRNA.UAS.L.cKa}

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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