FB2026_02 , released June 18, 2026
Allele: Dmel\Arl6IP1KO1
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General Information
Symbol
Dmel\Arl6IP1KO1
Species
D. melanogaster
Name
FlyBase ID
FBal0373684
Feature type
allele
Associated gene
Dmel\Arl6IP1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Byrne et al., 2022)
Mutagen
CRISPR/Cas9
(Byrne et al., 2022)
Progenitor genotype
Cytology
Description

5bp deletion within Arl6IP1; results in a frameshift from residue 27 and a premature stop codon.

(Byrne et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:16,644,074..16,644,078 [+]
Comment:

A 5bp deletion starting in codon 27 of Arl6IP1 rsults in a framshift and early translation termination.

(Byrne et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia 61
      CEA
      (Byrne et al., 2022)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Arl6IP1KO1 homozygotes are viable but adults show a progressive decrease in climbing ability. In third instar larvae, axon terminals of long motor neurons (i.e. targeting A7) display disrupted ER morphology, as well as significant elongation of mitochondria; axon bundles show an increased number of lipid droplets.

      (Byrne et al., 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Arl6IP1 KO1
      (Byrne et al., 2022)
      Arl6IP1KO1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)