FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Arl6IP1KO2
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General Information
Symbol
Dmel\Arl6IP1KO2
Species
D. melanogaster
Name
FlyBase ID
FBal0373685
Feature type
allele
Associated gene
Dmel\Arl6IP1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Byrne et al., 2022)
Mutagen
CRISPR/Cas9
(Byrne et al., 2022)
gene targeting by homologous recombination
(Byrne et al., 2022)
Progenitor genotype
Cytology
Description

Two separate insertions (9bp and 1bp) within Arl6IP1; the first three bases of the 9bp insertion result in a premature stop codon.

(Byrne et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:16,644,048..16,644,079 [+]
Comment:

A stop codon is introduced after amino acid 18 of Arl6IP1. This is the result of the indicated region being replaced with TGATAATAGTTGGAGCCTTTCCGGACAGCGATTGTTGGAGCC.

Inserted_sequence:

TGATAATAGTTGGAGCCTTTCCGGACAGCGATTGTTGGAGCC

(Byrne et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  hereditary spastic paraplegia 61
      CEA
      (Byrne et al., 2022)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Arl6IP1KO2 homozygotes are viable but adults show a progressive decrease in climbing ability. In third instar larvae, axon terminals of long motor neurons (i.e. targeting A7) display disrupted ER morphology, as well as significant elongation of mitochondria; axon bundles show an increased number of lipid droplets.

      (Byrne et al., 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Arl6IP1 KO2
      (Byrne et al., 2022)
      Arl6IP1KO2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)