FB2026_02 , released June 18, 2026
Allele: Dmel\tadr2
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General Information
Symbol
Dmel\tadr2
Species
D. melanogaster
Name
FlyBase ID
FBal0373714
Feature type
allele
Associated gene
Dmel\tadr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Han et al., 2022)
Mutagen
CRISPR/Cas9
(Han et al., 2022)
Progenitor genotype
Cytology
Description

Elimination of 665 bp within the tadr locus, including all of exon 4 and parts of exons 3 and 5. This leads to a deletion for 244 nt in the spliced tadr mRNA, resulting in a frame shift at the truncated site.

(Han et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:21,077,682..21,078,346 [+]
Comment:

A 665bp deletion in tadr starting in codon 94. This results in a deletion of 244bp in the mRNA, a frameshift, and early translation termination.

(Han et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Electroretinograms in tadr2 adults show loss of ON/OFF transients in response to light.

      (Han et al., 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      tadr2 has retina phenotype, suppressible by Scer\GAL4GMR.PU/CG13248UAS.cHa

      (Han et al., 2022)

      tadr2 has retina phenotype, suppressible by Hsap\SLC38A3UAS.cHa/Scer\GAL4GMR.PU

      (Han et al., 2022)
      NOT suppressed by
      Statement
      Reference

      tadr2 has retina phenotype, non-suppressible by Scer\GAL4GMR.PU/CG13248UAS.cHa

      (Han et al., 2022)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      tadr2 is rescued by tadrUAS.cHa/Scer\GAL4GMR.PU

      (Han et al., 2022)

      tadr2 is rescued by tadrtrp.PH

      (Han et al., 2022)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      tadr2
      (Han et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)