FB2026_02 , released June 18, 2026
Allele: Dmel\TmepEx
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General Information
Symbol
Dmel\TmepEx
Species
D. melanogaster
Name
FlyBase ID
FBal0373924
Feature type
allele
Associated gene
Dmel\Tmep
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Cho et al., 2022)
Mutagen
gene targeting by homologous recombination
(Cho et al., 2022)
Progenitor genotype
Cytology
Description

A 16-base deletion in the first coding exon of Tmep (bases 20-35 in the open reading frame) that is predicted to create a nonsense mutation seven amino acids from the N-terminus, affecting both the short and long isoforms.

(Cho et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:1,572,006..1,572,021 [+]
Comment:

A 16-base deletion in the first coding exon of Tmep (bases 20-35 in the open reading frame) that is predicted to create a nonsense mutation seven amino acids.

(Cho et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TmepEx/Df(3L)Exel6087 females, but not males, show decreased climbing ability after disorientation, as compared to controls. female third instar larvae show reduced body contraction (crawling) rates compared to controls. In TmepEx/Df(3L)Exel6087 females, muscle 6/7 NMJs show increased branch number, as well as increased number of satellite boutons and active zones.

      In TmepEx/Df(3L)Exel6087 males and females the NMJ responds more than once to a stimulus; occasionally a single stimulus induces over 20 EJPs over the 5s post-stimulus period. While the first EJP does not vary in amplitude, all ectopic EJPs have significantly reduced amplitudes; The amplitudes of mEJPs is decreased n females only.

      (Cho et al., 2022)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      TmepEx
      (Cho et al., 2022)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)