FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cap-H2cc3
Open Close
General Information
Symbol
Dmel\Cap-H2cc3
Species
D. melanogaster
Name
FlyBase ID
FBal0374573
Feature type
allele
Associated gene
Dmel\Cap-H2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Vernizzi and Lehner, 2021)
Progenitor genotype
Cytology
Description

5bp frame-shifting deletion within the Cap-H2 coding sequence, resulting in a premature stop codon. Also contains a second deletion in the Cap-H2 coding sequence, further downstream (the second deletion is 918bp, and is identical to the lesion found in Cap-H2cc1).

(Vernizzi and Lehner, 2021)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:10,763,169..10,763,173 [+]
Comment:

A 5bp frameshifting deletion in Cap-H2 bounded by sequences 5' ATGTCGGACGACAAGCGCTTCAACG .. GGCTTTGTAAAGT 3'. This allele also contains a 918bp deletion further downstream (the same deletion as in Cap-H2cc1.

(Vernizzi and Lehner, 2021)
point_mutation
3R:10,763,744..10,764,661 [+]
Comment:

A 918bp frameshifting deletion in Cap-H2 bounded by sequences 5' AGCGAAGTCGAG .. CCCACATTTGAC 3'. This allele also contains a 5bp frameshifting deletion further upstream.

(Vernizzi and Lehner, 2021)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Homozygous lethal, but hemizygous viable, suggesting the presence of second-site recessive lethal mutation on the chromosome.

      (Vernizzi and Lehner, 2021)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Cap-H2cc3
      (Vernizzi and Lehner, 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)